Document Type : Original Article
Researcher
Allameh Tabataba'i University
Ministerial Ethics Committee
Investigating insulin receptor expression in immune cells is crucial for understanding the intricate relationship between insulin, immune function, and their effects on lifespan and age-related immune dysfunction. Recent research highlights an immune-endocrine axis where insulin plays a central role in immune cell regulation and metabolism, involving complex signaling pathways. With aging, this balance is disrupted, leading to increased inflammatory cell production and persistent hyperinflammatory loops, contributing to immune system compromise and chronic inflammation. Factors like weight gain and aging can induce insulin resistance, exacerbating immune dysfunction and age-related diseases. Recognizing the role of insulin receptor signaling in immune cells is crucial for understanding overweight and age-related immune dysfunction. Aging also remodels the immune system, increasing susceptibility to infections, latent virus reactivation, reduced vaccine efficacy, and higher rates of autoimmunity and cancer. Combining endurance, resistance, balance, and flexibility exercises is effective for elderly health, particularly resistance training, which improves insulin sensitivity. Understanding insulin's immune molecular effects and the impact of combined exercise, especially resistance training, is essential for targeted strategies